✦ LIBER ✦

Structure and function of CooA, a novel transcriptional regulator containing a b-type heme as a CO sensor

✍ Scribed by Shigetoshi Aono; Hiroshi Nakajima

Book ID: 104111952
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 163 KB
Volume: 190-192
Category: Article
ISSN: 0010-8545
DOI: 10.1016/s0010-8545(99)00070-3

No coin nor oath required. For personal study only.

✦ Synopsis

CooA is a transcriptional activator containing a b-type heme as a prosthetic group. The heme in CooA is in the six-coordinate form in the ferric and ferrous state. Although the ferrous heme is coordinated by two axial ligands, it can react easily with CO to form the CO-bound heme under physiological conditions. Replacement of the heme's axial ligand by CO triggers the activation of CooA, which causes some conformational change around the heme and finally in the whole molecule. In this paper, the coordination structure of the heme in CooA and the mechanism of activation of CooA by CO were studied by spectroscopic analysis of the wild-type and some mutant CooAs. The amino acid residues responsible for www.elsevier.com/locate/ccr

📜 SIMILAR VOLUMES

Single Transduction in the Transcription

Single Transduction in the Transcriptional Activator CooA Containing a Heme-Based CO Sensor: Isolation of a Dominant Positive Mutant Which Is Active as the Transcriptional Activator Even in the Absence of CO

✍ Shigetoshi Aono; Takatoshi Matsuo; Takeshi Shimono; Kei Ohkubo; Hidenori Takasak 📂 Article 📅 1997 🏛 Elsevier Science 🌐 English ⚖ 90 KB

Characterization of a c-type heme-contai

Characterization of a c-type heme-containing PAS sensor domain from Geobacter sulfurreducens representing a novel family of periplasmic sensors in Geobacteraceae and other bacteria

✍ Yuri Y. Londer; Irina S. Dementieva; Cori A. D'Ausilio; P. Raj Pokkuluri; Marian 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 367 KB

B-ATF functions as a negative regulator

B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos

✍ Echlin, Deborah R; Tae, Hyi-Jeong; Mitin, Natalia; Taparowsky, Elizabeth J 📂 Article 📅 2000 🏛 Nature Publishing Group 🌐 English ⚖ 516 KB

Functional screening of five PYPAF famil

Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-κB and caspase-1

✍ Jill M. Grenier; Lin Wang; Gulam A. Manji; Waan-Jeng Huang; Amal Al-Garawi; Roxa 📂 Article 📅 2002 🏛 Elsevier Science 🌐 English ⚖ 376 KB

Wave attenuation in waveguide containing

Wave attenuation in waveguide containing two-layer semiconductor-dielectric structure as a function of conductivity and thickness of semiconductor

✍ V. I. Zanin; D. A. Usanov; V. B. Feklistov 📂 Article 📅 1992 🏛 Springer US 🌐 English ⚖ 376 KB

Two Functions of the C-Terminal Domain o

Two Functions of the C-Terminal Domain of Escherichia coli Rob: Mediating “Sequestration–Dispersal” as a Novel Off–On Switch for Regulating Rob’s Activity as a Transcription Activator and Preventing Degradation of Rob by Lon Protease

✍ Kevin L. Griffith; M. Megan Fitzpatrick; Edward F. Keen III; Richard E. Wolf Jr 📂 Article 📅 2009 🏛 Elsevier Science 🌐 English ⚖ 571 KB