Energetics of protein structure and fold
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David P. Goldenberg; Thomas E. Creighton
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Article
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1985
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Wiley (John Wiley & Sons)
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English
β 930 KB
The available experimental data on the kinetics of unfolding and refolding of small proteins are reviewed. Excluding slow transitions in the unfolded protein due to cis- trans isomerization of peptide bonds, the rate-limiting transition state in both unfolding and refolding is concluded to be a high