Structure and conformation of peptides: N-benzyloxycarboyl-(γ-ethyl)-L-glutamyl-(γ-ethyl)-L-glutamic acid ethyl ester

✍ Scribed by Ettore Benedetti; Benedetto Di Blasio; Vincenzo Pavone; Carlo Pedone; Gabriel Germain; Murray Goodman

• Publisher: Wiley (John Wiley & Sons)
• Year: 1979
• Tongue: English
• Weight: 266 KB
• Volume: 18
• Category: Article
• ISSN: 0006-3525
• DOI: 10.1002/bip.1979.360180304

✦ Synopsis

Synopsis

C Z ~H : ~~N ~O ~, orthorhombic, B212121; a = 39.432 (lo), b = 14.061 ( 5 ) , c = 4.850 (2) A, M = 494 a.m.u., Z = 4, Dm = 1.22 g cm-:', Dr = 1.22 g cm-3, R = 0.13 for 1205 observed reflections alter refinement with isotropic thermal factors. The urethane and amide bonds are in the trans configuration, as well as all the ester groups. The (c and $ angles of the L-glutamyl residues fall in the &structure region of the Ramachandran's plot; the molecule is rather flat with the amide plane almost parallel to the c axis along which two hydrogen bonds hold the molecules together to form long rows in a "parallel pleated-sheet'' fashion.