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Structure and Assembly of the Heterotrimeric and Homotrimeric C-Propeptides of Type I Collagen: Significance of the α2(I) Chain †

✍ Scribed by Malone, James P.; Alvares, Keith; Veis, Arthur


Book ID
127092352
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
727 KB
Volume
44
Category
Article
ISSN
0006-2960

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Role of the pro-α2(I) COOH-terminal regi
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Procollagen (Type I) contains a noncollagenous COOH-terminal propeptide (C-propeptide) hypothesized to be important in directing chain association and alignment during assembly. We previously expressed human pro-␣2(I) cDNA in rat liver epithelial cells, W8, that produce only pro-␣1(I) trimer collage

Role of the pro-α2(I) COOH-terminal regi
✍ Sharon A. Doyle; Barbara D. Smith 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 141 KB 👁 1 views

Collagen biosynthesis is a complex process that begins with the association of three procollagen chains. A series of conserved intra-and interchain disulfide bonds in the carboxyl-terminal region of the procollagen chains, or C-propeptide, has been hypothesized to play an important role in the nucle