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Structure and activity of a functional derivative of Clostridium botulinum neurotoxin B

✍ Scribed by Geoffrey Masuyer; Matthew Beard; Verity A. Cadd; John A. Chaddock; K. Ravi Acharya

Book ID
116697142
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
583 KB
Volume
174
Category
Article
ISSN
1047-8477

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Structure and enzymatic activity of botu
Structure and enzymatic activity of botulinum neurotoxins
✍ Subramanyam Swaminathan; Subramanian Eswaramoorthy; Desigan Kumaran πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 244 KB

The structure of botulinum neurotoxin type B (BoNT/B) is analyzed, and it is demonstrated that the carbonyl oxygen of the scissile bond comes close to the zinc ion to form a Michaelis complex. The hydrated carbonyl is activated by the nucleophilic water, which moves closer to Glu 230 to form hydroge