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Structure and absolute stereochemistry of the new cyclolinteinol and cyclolinteinol acetate, macrophage activation modulators

โœ Scribed by Alfonso Carotenuto; Ernesto Fattorusso; Virginia Lanzotti; Silvana Magno; Rosa Carnuccio; Fulvio D'Acquisto


Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
348 KB
Volume
53
Category
Article
ISSN
0040-4020

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โœฆ Synopsis


Two novel sesterterpenes, cyclolinteinol (5) and cyclolinteinol acetate (6), have been isolated from the Caribbean sponge Cacospongia cf. linteiformis. Their structures and absolute stereochemistry were determined using spectroscopic and chemical methods. The new compounds (5, 6) and the related compounds 1-3, previously isolated from the sponge, strongly inhibited NO production by LPSstimulated murine macrophages J774.


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