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Structure-activity Study of Endomorphins Analogs with C- terminal Substitution

✍ Scribed by Pin Gong; Fuxin Chen; Rui Wang


Book ID
116846475
Publisher
Elsevier
Year
2011
Weight
423 KB
Volume
8
Category
Article
ISSN
1878-0296

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A number of analogs of the C-terminal hexapeptide of PBAN were prepared and tested in vivo for pheromonotropic activity in Helicoverpa zea. Peptides prepared with longer-chain omega-aminocarboxylic acids (Tyr-6-aminocaproyl-Leu-NH2 and Tyr-7-aminoheptanoyl-NH2) were active at 25 and 2.5 nmol. Acetyl