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Structure-activity studies on thiol derivatives of kynurenic acid

✍ Scribed by Moroni, F.; Alesiani, M.; Galli, A.; Carla, V.; Pellicciari, R.

Book ID
122914486
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
79 KB
Volume
22
Category
Article
ISSN
1043-6618

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A quantum-chemical structure᎐affinity relationship for kynurenic acid ## Ž . derivatives KA acting at the GlyrNMDA site is presented. The results of this study Ž . strongly suggest that these molecules bind to this site through three mechanisms: 1 a H Ž . bond between the N atom and an OH group o