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Structure Activity Studies of the Melanocortin-4 Receptor by in Vitro Mutagenesis: Identification of Agouti-Related Protein (AGRP), Melanocortin Agonist and Synthetic Peptide Antagonist Interaction Determinants †

✍ Scribed by Haskell-Luevano, Carrie; Cone, Roger D.; Monck, Eileen K.; Wan, Y.-P.


Book ID
127140221
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
244 KB
Volume
40
Category
Article
ISSN
0006-2960

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Current trends in the structure—activity
✍ Andrzej M. Wilczynski; Christine G. Joseph; Carrie Haskell-Luevano 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 264 KB

## Abstract Agouti‐related protein (AGRP) is an endogenous antagonist of the melanocortin‐3 and ‐4 (MC3R and MC4) G‐protein coupled receptors. The 87–132 amino acid C‐terminal domain of hAGRP possesses five disulfide bridges and a well‐defined three‐dimensional structure that displays full biologic