A computational lead-hopping exercise identified compound 4 as a structurally distinct P2X(7) receptor antagonist. Structure-activity relationships (SAR) of a series of pyroglutamic acid amide analogues of 4 were investigated and compound 31 was identified as a potent P2X(7) antagonist with excellen
✦ LIBER ✦
Structure-activity relationships (SAR) of the 3-alkyl substituents among a series of hydroxyacetophenone leukotriene antagonists
✍ Scribed by W. S. Marshall; C. A. Whitesitt; T. Goodson; C. Roman; L. Rinkema; J. H. Fleisch
- Publisher
- SP Birkhäuser Verlag Basel
- Year
- 1987
- Tongue
- English
- Weight
- 150 KB
- Volume
- 21
- Category
- Article
- ISSN
- 1420-908X
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