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Structure-Activity Relationships of G Protein-Coupled Receptors

✍ Scribed by Alfredo Ulloa-Aguirre; Dinesh Stanislaus; Jo Ann Janovick; P.Michael Conn


Book ID
114179622
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
430 KB
Volume
30
Category
Article
ISSN
0188-4409

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## Abstract It has been recently established that G‐protein‐coupled receptors (GPCRs) can be constitutively active, i.e., they can be active in the absence of an agonist. This activity can be inhibited by so‐called inverse agonists. For a number of GPCRs, such inverse agonists have been developed a