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Structure-activity relationships of epoxides: induction of sister-chromatid exchanges in Chinese hamster V79 cells

✍ Scribed by Wilhelm von der Hude; Silke Carstensen; Günter Obe

Book ID
113193986
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
800 KB
Volume
249
Category
Article
ISSN
0027-5107

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✍ Rudolf Trust; Barbara Bach 📂 Article 📅 1985 🏛 Springer 🌐 English ⚖ 510 KB

Glutathione (GSH) dissolved in Eagle's MEM and added to cultures of V79-E cells in concentrations between 2.5 X 10 -4 and 10 -3 moles/l for 1 h induces a dose-dependent cell cycle delay, sister chromatid exchanges and clastogenic damage. 7-8% of the metaphases showed endoreduplication at a recovery