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Structure-Activity Relationships of Biologically Active Analogs and Fragments of Neuropeptide Y

✍ Scribed by M. A. SPICER; J. H. BOUBLIK; R. D. FEINSTEIN; M. GOODMAN; M. BROWN; J. RIVIER


Book ID
119865339
Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
132 KB
Volume
611
Category
Article
ISSN
0890-6564

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A number of analogs of the C-terminal hexapeptide of PBAN were prepared and tested in vivo for pheromonotropic activity in Helicoverpa zea. Peptides prepared with longer-chain omega-aminocarboxylic acids (Tyr-6-aminocaproyl-Leu-NH2 and Tyr-7-aminoheptanoyl-NH2) were active at 25 and 2.5 nmol. Acetyl