𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Structure-activity relationship study of a scorpion toxin with high affinity for apamin-sensitive potassium channels by means of the solution structure of analogues

✍ Scribed by INISAN, A.G. ;MEUNIER, S. ;FEDELLI, O. ;ALTBACH, M. ;FREMONT, V. ;SABATIER, J.-M. ;THÉVAN, A. ;BERNASSAU, J.-M. ;CAMBILLAU, C. ;DARBON, H.

Book ID
115099777
Publisher
Wiley (Blackwell Publishing)
Year
2009
Tongue
English
Weight
602 KB
Volume
45
Category
Article
ISSN
0367-8377

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Solution structure of P01, a natural sco
Solution structure of P01, a natural scorpion peptide structurally analogous to scorpion toxins specific for apamin-sensitive potassium channel
✍ Blanc, E.; Fremont, V.; Sizun, P.; Meunier, S.; Van Rietschoten, J.; Thevand, A. 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 832 KB

The venom of the North African scorpion Androctonus mauretanicus mauretanicus possesses numerous highly active neurotoxins that specifically bind to various ion channels. One of these, P05, has been found to bind specifically to calcium-activated potassium channels and also to compete with apamin, a

Solution structure of TsKapa, a charybdo
Solution structure of TsKapa, a charybdotoxin-like scorpion toxin from Tityus serrulatus with high affinity for apamin-sensitive Ca2+-activated K+ channels
✍ E. Blanc; C. Lecomte; J. Van Rietschoten; J.M. Sabatier; H. Darbon 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 802 KB

TsKapa (TsK), purified from the Buthidae Tityus serrulatus is a very high potent ligand for small-conductance apaminsensitive calcium-activated potassium channels (SK). It is able to efficiently compete with apamin for binding on this channel (K 0.5 ‫؍‬ 0.3 nM) [Legros, C. et al., FEBS Lett. 390:81-

Solution structure of maurotoxin, a scor
Solution structure of maurotoxin, a scorpion toxin from Scorpio maurus, with high affinity for voltage-gated potassium channels
✍ E. Blanc; J.M. Sabatier; R. Kharrat; S. Meunier; M. El Ayeb; J. Van Rietschoten; 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 488 KB 👁 2 views

Maurotoxin (MTX), purified from the scorpionid Scorpio maurus is a potent ligand for potassium channels. It shows a broad specificity as being active on Kv1.1 (Kd ‫؍‬ 37 nM), Kv1.2 (Kd ‫؍‬ 0.8 nM), Kv1.3 (Kd ‫؍‬ 150 nM) voltage-gated potassium channels, as well as on small-conductance calcium-activa