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Structure-Activity Relationship Studies of CNS Agents, XV: N-[ω-(4-Aryl-1-piperazinyl)alkyl]-2-oxo-1,2,3,4-tetrahydroquinolines and -4-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indoles: New, Highly Potent 5-HT1A Ligands ωN-[ω-(4-Aryl-1-piperazinyl)alkyl]-2-oxo-1,2,3,4-tetrahydrochinoline und -4-oxo-1,2,3,4-tetrahydropyrazino-[1,2-a]indole: Neue starke 5-HT1A Liganden

✍ Scribed by Jerzy L. Mokrosz; Beata Duszyńska; Maria H. Paluchowska


Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
198 KB
Volume
327
Category
Article
ISSN
0365-6233

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Two new natural products, N- (2-methyl-3-oxodec-8-enoyl)corresponding acid chloride, in order to acylate Meldrum's acid. Subsequent aminolysis with pyrrolidine, followed by 2-pyrroline (2) and 2-(hept-5-enyl)-3-methyl-4-oxo-6,7,8,8atetrahydro-4H-pyrrolo[2,1-b]-1,3-oxazine (3), have been methylation