✦ LIBER ✦
Structure-activity relationship homology (SARAH): a conceptual framework for drug discovery in the genomic era
✍ Scribed by Stephen V Frye
- Book ID
- 104375799
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 470 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1074-5521
No coin nor oath required. For personal study only.
✦ Synopsis
Extension of the traditional pharmacological approach of protein target dassification to whole target systems has the potential to relate elements of protein sequence to the structure-activity relationship (SAR) of small molecules that can modulate protein action. Grouping potential drug discovery targets into families based on the relatedness of their SAR provides a means to translate the information from genome-sequencing efforts into knowledge that will aid in the discovery of drugs.