Structure activity relations of some indolealkylamines in comparison to phenethylamines on motor activity and acquisition of avoidance behavior

✍ Scribed by Michael R. Vasko; Michael P. Lutz; Edward F. Domino

• Book ID: 104775046
• Publisher: Springer
• Year: 1974
• Tongue: English
• Weight: 521 KB
• Volume: 36
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00441381

✦ Synopsis

The structure-activity relationships (SAR) of various known hallucinogenic and nonhallucinogenie indolealkylamine and phenethylamine derivatives were compared on two different behaviors: mouse locomotor activity and acquisition of one-way avoidance behavior in the rat. Certain parallels were observed between the two classes of compounds, a-Methyl substituted derivatives of the indoles and phenethylamines increased dramatically psychomotor stimulant effects. Acquisition of one-way avoidance behavior was reduced by the more potent hallucinogens and psychomotor stimulants of both classes. Pargyline pretreatment enhanced the psychomotor stimulant effects of all of ~he compounds tested except 5-hydroxytryptamine (5-tIT), d-amphetamine, mescaline and lysergic acid diethylamide (LSD-25).