Structure-activity relations in organophosphorus-inhibited acetylcholinesterase reactivators II: Methiodides of hydroxyimino derivatives of 1-pyridyl-2-phenylethanes

✍ Scribed by Palmarisa Franchetti; Mario Grifantini; Sante Martelli

• Publisher: John Wiley and Sons
• Year: 1969
• Tongue: English
• Weight: 465 KB
• Volume: 58
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600580714

✦ Synopsis

A series of methiodides from syrz-Zhydroxyimino-1pyridyl-2-phenylethanes, syn-1-hydroxyimino-1-pyridyl-Zphenylethan-2-ones, syn-and anti-2-hydroxyimino-l-pyridyl-2-phenylethan-1-ones, and syn-1,2-di(hydroxyimino)-l-pyridyl-2-phenylethanes was prepared. The influence of the structure of these new compounds on the in uitro reactivation of acetylcholinesterase inhibited by TEPP or DFP was investigated. The results obtained confirmed that quaternary pyridine derivatives containing a hydroxyimino group in the position of the side chain generally keep a reactivating ability, in whatever position the connection with the ring may be; in some cases this activity is higher than that of the isomer containing the same group in the a position.

Keyphrases 0 Acetylcholinesterase reactivators-structure-activity relationships 0 Organophosphorus-inhibited cholinesterase reactivators 0 l-Pyridyl-2-phenylethanes, hydroxyimino methiodides-synthesis 0 UV spectrophotometry-identity, structure