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Structure-activity correlation for a series of isatin derivatives, inhibitors of caspase 3

✍ Scribed by I. G. Tsygankova; S. M. Zhenodarova

Book ID
111460024
Publisher
Springer
Year
2009
Tongue
English
Weight
176 KB
Volume
79
Category
Article
ISSN
1070-3632

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Various aryloxy methyl ketones of the 1-naphthyloxyacetyl-Val-Asp backbone have been prepared. A systematic study of their structure-activity relationship (SAR) related to caspases 1, 3, 6, and 8 is reported. Highly potent irreversible broad-spectrum caspase inhibitors have been identified. Their ef