Structure-Activity Correlation as a Predictive Tool in Toxicology: Fundamentals Methods, and Applications. Edited by Leon Goldberg. Hemisphere Publishing Corp., 19 W. 44Th St., New York, NY 10036. 330 pp. 16 × 23 cm. Price $49.50
✍ Scribed by William B. Porter
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 264 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
✦ Synopsis
This book tries to offer something for the medicinal chemist, the renal pharmacologist and physiologist, and the physician. With its interdisciplinary approach it can be highly recommended to all three, but particularly to the medicinal chemist because of its emphasis on structureactivity relationships and possible future directions for diuretic research.
Keviruvd by Gregory M. Shutske Department of ('hemica1 Research Hoechst-Roussel Pharmaceuticals, Inc Sompruille, NJ 08876 Polyether Antibiotics, Volume 2: N a t u r a l l y O c c u r r i n g Acid Ionophores. Edited by JOHN W. WESLEY. Marcel Dekker, 270 Madison Avenue, New York, NY 10016. 1983.415 pp. 15 X 23 cm. Price $65.00 (20% higher outside the IJ.S. and Canada).
This work is the second of a two-volume set on polyether antibiotics. As the title indicates, it concentrates on the chemical aspects in this field whereas the microbiology, biosynthesis, pharmacology, and veterinary applications were covered in the first volume. The editor has chosen an excellent array of contributing authors, each of whom has done important original work in this field. The resulting volume therefore has the added advantage of being authoritative as well as informative.
The first chapter by Yoshito Kishi is an excellent review of the total synthesis of many of the polyethers which not only includes the author's own contributions, but also a critical view of other major contributors to this field. This is followed by a review of known chemical modifications of this class of antibiotics, which focuses attention on the lack of progress in this aspect of polyether chemistry in light of the high level of understanding brought to bear by X-ray crystallography. The remainder of this book covers the major contributions made to polyether chemistry by physical chemistry including X-ray crystallography, mass spectrometry.