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Structural studies on the interaction of saccharides and glycomimetics with galectin-1: A 3D perspective using a combined molecular modeling and NMR approach

✍ Scribed by Martín-Santamaría, Sonsoles; Gabius, Hans-Joachim; Jiménez-Barbero, Jesús


Book ID
120333350
Publisher
International Union of Pure and Applied Chemistry
Year
2011
Tongue
English
Weight
919 KB
Volume
84
Category
Article
ISSN
0033-4545

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✦ Synopsis


The interaction of a variety of saccharides and mimetics thereof with lectin receptors has been studied using a combination of molecular modeling protocols and NMR spectroscopy techniques. It is shown that both methods complement each other in a synergistic manner to provide a detailed perspective of the conformational and structural features of the recognition process.


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