Structural studies on molecular complexes V: Crystal structures of sulfathiazole—sulfanilamide and sulfathiazole—theophylline complexes

✍ Scribed by Eli Shefter; Phyllis Sackman

• Publisher: John Wiley and Sons
• Year: 1971
• Tongue: English
• Weight: 533 KB
• Volume: 60
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600600228

✦ Synopsis

The crystal structures of two sulfathiazole complexes, one involving theophylline and the other sulfanilamide, were determined by X-ray diffraction methods. The complexes are 1 : 1 adducts held together by hydrogen bonding. The hydrogen-bonding schemes in the two complexes are quite different. In the theophylline complex the aromatic amino group of sulfathiazole is involved in the principal intermolecular hydrogen bonds; whereas in the sul-fanilamide complex, one of the sulfathiazole oxygens is the dominant participant. Sulfathiazole is present in both structures in the imido-configuration rather than the amido-form.