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Structural studies of constitutive nitric oxide synthases with diatomic ligands bound

✍ Scribed by Huiying Li; Jotaro Igarashi; Joumana Jamal; Weiping Yang; Thomas L. Poulos


Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
596 KB
Volume
11
Category
Article
ISSN
1432-1327

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Identification of potent and selective inhibitors of inducible nitric oxide synthase (NOS) is of great interest because of their therapeutic potential for treatment of diseases mediated by excess production of nitric oxide. We present here a comparison of potency and selectivity for amino acid and n