Fifty-two cultures grown under standard conditions from separate subclones of haploid Saccharomyces strain X2180-1A were exposed to standard treatment with nitrous acid (NA). When the duration of NA-treatment was the same:a) cell survival varied markedly and the frequency distribution of its values
Structural specificity in the lethal and mutagenic activity of furocoumarins in yeast cells
β Scribed by D. Averbeck; Prakash Chandra; R. K. Biswas
- Publisher
- Springer-Verlag
- Year
- 1975
- Tongue
- English
- Weight
- 763 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0301-634X
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Yeast cultures progressing from the exponential to the stationary phase of growth showed changes in cell sensitivity to physical agents such as UV light, heat shock at 52 degrees C and the chemical mutagens ethyl methane sulphonate, nitrous acid and mitomycin C. Exponential phree chemicals. The incr
In the presence of near-UV radiation (UVA) furocoumarins (psoralens) photoinduce defined lesions in DNA, i.e. monoadducts and interstrand crosslinks. Their use in photochemotherapy (psoralen plus UVA (PUVA) treatment) and cosmetics raises questions concerning the repairability of these lesions and t