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Structural requirements for uptake and recognition of CpG oligonucleotides

โœ Scribed by Klaus Heeg; Alexander Dalpke; Mirjam Peter; Stefan Zimmermann

Book ID
116558299
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
187 KB
Volume
298
Category
Article
ISSN
1438-4221

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The structure of the cell-permeable h-helical amphipathic model peptide FLUOS-KLALKLALKA-LKAALKLA-NH 2 (I) was modified stepwise with respect to its helix parameters hydrophobicity, hydrophobic moment and hydrophilic face as well as molecular size and charge. Cellular uptake and membrane destabilizi