Structural requirements for calmodulin binding to membrane-associated guanylate kinase homologs

Minimal residues in linker domain of syn

Minimal residues in linker domain of syntaxin 1A required for binding affinity to Ca2+/calmodulin-dependent protein kinase II

✍ Kazushige Nomura; Akihiro Ohyama; Yoshiaki Komiya; Michihiro Igarashi 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 204 KB

## Abstract The linker domain is important for the conformational change syntaxin 1A, which enables it to act as a SNARE for exocytosis. We found that when applied exogenously, the linker domain is a potent inhibitor of exocytosis through inhibiting interaction between autophosphorylated CaMKII and