The Ͱ-cyano-ͱ-hydroxy enamide 1 is an inhibitor of human dihydroorotate dehydrogenase (IC 50 ϭ 0.26 ȐM), the rate-limiting enzyme in the de novo pyrimidine biosynthesis. A structure-activity analysis based on selected derivatives of 1 demonstrates that both its structural characteristics and its phy
✦ LIBER ✦
Structural requirements for bioactivation of anticonvulsants to cytotoxic metabolites in vitro.
✍ Scribed by RJ Riley; NR Kitteringham; BK Park
- Book ID
- 117944755
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 748 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0306-5251
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