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Structural requirements for antiviral activity in nucleosides

✍ Scribed by Piet Herdewijn

Book ID
114385483
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
867 KB
Volume
2
Category
Article
ISSN
1359-6446

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## Abstract Thirty‐three 1‐β‐D‐pentofuranosylcytosine nucleosides were examined as substrates of crude cytidine deaminase from mouse kidney. In addition to previous observations of structural features in substrates required for enzymatic deamination [e.g., a free 3′‐hydroxyl in the β€˜down’ ribo (ara