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Structural properties of orexins for activation of their receptors

✍ Scribed by Manja Lang; Bernd Bufe; Silvia De Pol; Oliver Reiser; Wolfgang Meyerhof; Annette G. Beck-Sickinger

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 257 KB
Volume: 12
Category: Article
ISSN: 1075-2617
DOI: 10.1002/psc.716

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## Abstract Orexins‐A and B, also called hypocretins‐1 and 2, respectively, are neuropeptides that regulate feeding and sleep‐wakefulness by binding to two orphan G protein‐coupled receptors named orexin‐1 (OX~1~R) and orexin‐2 (OX~2~R). The sequences and functions of orexins‐A and B are similar to