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Structural properties and stability of PNA with (2′R,4′R)- and (2′R,4′S)-prolyl-(1S,2S)-2-aminocyclopentanecarboxylic acid backbone binding to DNA: A molecular dynamics simulation study

✍ Scribed by Poomsuk, Nattawee; Siriwong, Khatcharin


Book ID
121839393
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
866 KB
Volume
588
Category
Article
ISSN
0009-2614

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A new pyrrolidinyl peptide nucleic acid (PNA) comprising of an alternate sequence of 4 0 -nucleobasemodified proline with (2 0 R,4 0 S) configuration and a (1S,2S)-2-aminocyclopentanecarboxylic acid [(2 0 R,4 0 S)-acpcPNA] backbone was synthesized and its DNA-, RNA-and self-pairing properties studie