✦ LIBER ✦
Structural polymorphism of human Ia antigens recognized by the monoclonal antibody 12 and by cross-reacting I-Ek-specific alloantibodies
✍ Scribed by M. Igarashi; F. Obata; M. Yoshii; N. Kashiwagi; S. Ferrone
- Publisher
- Springer-Verlag
- Year
- 1984
- Tongue
- English
- Weight
- 630 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0093-7711
No coin nor oath required. For personal study only.
✦ Synopsis
The gene products of the human and murine I region display a high degree of homology in their primary amino acid sequence (Silver et al. 1979, Bono andStrominger 1982). This structural similarity is paralleled by cross-hybridization of HLA-D cDNA probes with murine cosmids containing/-region genes (Steinmetz et al. 1982) and by serologic cross-reactivity of mouse class II-specific alloantisera and monoclonal antibodies with human B lymphoid cells (