Probing the activation of protein C by t
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Karin E. Knobe; Ann Berntsdotter; Lei Shen; John Morser; BjΓΆrn DahlbΓ€ck; Bruno O
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Article
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1999
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John Wiley and Sons
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English
β 647 KB
Protein C (PC) is activated to an essential anticoagulant enzyme (activated PC or APC) by thrombin (T) bound to thrombomodulin (TM), a membrane receptor present on the surface of endothelial cells. The understanding of this complex biological system is in part limited due to the lack of integration