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Structural Model of the mAb 806-EGFR Complex Using Computational Docking followed by Computational and Experimental Mutagenesis

✍ Scribed by Arvind Sivasubramanian; Ginger Chao; Heather M. Pressler; K. Dane Wittrup; Jeffrey J. Gray


Book ID
113918604
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
687 KB
Volume
14
Category
Article
ISSN
0969-2126

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Protein C (PC) is activated to an essential anticoagulant enzyme (activated PC or APC) by thrombin (T) bound to thrombomodulin (TM), a membrane receptor present on the surface of endothelial cells. The understanding of this complex biological system is in part limited due to the lack of integration