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Structural Mechanisms of Inactivation in Scabies Mite Serine Protease Paralogues

โœ Scribed by Katja Fischer; Christopher G. Langendorf; James A. Irving; Simone Reynolds; Charlene Willis; Simone Beckham; Ruby H.P. Law; Sundy Yang; Tanya A. Bashtannyk-Puhalovich; Sheena McGowan; James C. Whisstock; Robert N. Pike; David J. Kemp; Ashley M. Buckle


Book ID
116664131
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
735 KB
Volume
390
Category
Article
ISSN
0022-2836

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โœ James C. Powers; Chih-Min Kam; Lakshmi Narasimhan; Joszef Oleksyszyn; Maria A. H ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 781 KB

Isocoumarins are potent mechanism-based heterocyclic irreversible inhibitors for a variety of serine proteases. Most serine proteases are inhibited by the general serine protease inhibitor 3,4-dichloroisocoumarin, whereas isocoumarins containing hydrophobic 7-acylamino groups are potent inhibitors f