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Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates

✍ Scribed by Safrany, Stephen T; Alessi, Dario R; van Aalten, Daan M F; Komander, David; Fairservice, Alison; Deak, Maria; Kular, Gursant S; Prescott, Alan R; Peter Downes, C

Book ID
110030772
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
550 KB
Volume
23
Category
Article
ISSN
0261-4189

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Prothymosin ␣ gene expression accompanies growth of all mammalian cells. The protein, which is abundant, exceedingly acidic, and localized to the nucleus, is further distinguished by the presence of clustered phosphorylated glutamic acid residues (Trumbore et al., 1997, J Biol Chem 272:26394 -26404)