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Structural insights into the effect of isonucleosides on B-DNA duplexes using molecular-dynamics simulations

โœ Scribed by Hongwei Jin; Suxin Zheng; Zhanli Wang; Cheng Luo; Jianhua Shen; Hualiang Jiang; Liangren Zhang; Lihe Zhang


Publisher
Springer-Verlag
Year
2006
Tongue
English
Weight
451 KB
Volume
12
Category
Article
ISSN
1610-2940

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โœ Karol Miaskiewicz; John Miller; Rick Ornstein; Roman Osman ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Wiley (John Wiley & Sons) ๐ŸŒ English โš– 999 KB

The effect ofthymine lesions produced by radiation or oxidative damage on DNA structure was studied by molecular dynamics simulations ofnative and damaged DNA. Thymine in position 7 of native dodecamer d(CGCGAA TTCGCG)2 was replaced by one ofthe four thymine lesions 5-hydroxy-5,6-dihydrothymine, 6-h