Molecular dynamics simulations of the ef
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Karol Miaskiewicz; John Miller; Rick Ornstein; Roman Osman
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Article
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1995
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Wiley (John Wiley & Sons)
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English
โ 999 KB
The effect ofthymine lesions produced by radiation or oxidative damage on DNA structure was studied by molecular dynamics simulations ofnative and damaged DNA. Thymine in position 7 of native dodecamer d(CGCGAA TTCGCG)2 was replaced by one ofthe four thymine lesions 5-hydroxy-5,6-dihydrothymine, 6-h