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Structural insights into the conformational diversity of ClpP fromBacillus subtilis

✍ Scribed by Byung-Gil Lee; Min Kyung Kim; Hyun Kyu Song


Publisher
Korean Society for Molecular and Cellular Biology
Year
2011
Tongue
English
Weight
521 KB
Volume
32
Category
Article
ISSN
1016-8478

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## Abstract Bruton's tyrosine kinase (BTK) plays a key role in B cell receptor signaling and is considered a promising drug target for lymphoma and inflammatory diseases. We have determined the X‐ray crystal structures of BTK kinase domain in complex with six inhibitors from distinct chemical class