Insights into the conformational flexibi
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Andreas Kuglstatter; April Wong; Stan Tsing; Simon W. Lee; Yan Lou; Armando G. V
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Article
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2011
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Cold Spring Harbor Laboratory Press
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English
⚖ 463 KB
## Abstract Bruton's tyrosine kinase (BTK) plays a key role in B cell receptor signaling and is considered a promising drug target for lymphoma and inflammatory diseases. We have determined the X‐ray crystal structures of BTK kinase domain in complex with six inhibitors from distinct chemical class