The discovery and structureβactivity rel
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Brian Grella; Jessica Adams; James F. Berry; Greg Delahanty; Dana V. Ferraris; P
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Article
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2010
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Elsevier Science
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English
β 687 KB
A series of N-substituted 3-(2-mercaptoethyl)-1H-indole-2-carboxylic acids were synthesized as inhibitors of glutamate carboxypeptidase II (GCPII). Those containing carboxybenzyl or carboxyphenyl groups at the N-position exhibited potent inhibitory activity against GCPII. These indole-based compound