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Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III

✍ Scribed by Klara Hlouchova; Cyril Barinka; Jan Konvalinka; Jacek Lubkowski


Book ID
111313062
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
916 KB
Volume
276
Category
Article
ISSN
1432-1327

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A series of N-substituted 3-(2-mercaptoethyl)-1H-indole-2-carboxylic acids were synthesized as inhibitors of glutamate carboxypeptidase II (GCPII). Those containing carboxybenzyl or carboxyphenyl groups at the N-position exhibited potent inhibitory activity against GCPII. These indole-based compound