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Structural information from OH-stretching vibrations—XII. The orientation of the hydroxyl in 17-ethynyl-17-hydroxy- and 17-methyl-17-hydroxy steroids

✍ Scribed by T. Visser; J.H. van der Maas

Publisher: Elsevier Science
Year: 1983
Tongue: English
Weight: 376 KB
Volume: 39
Category: Article
ISSN: 1386-1425
DOI: 10.1016/0584-8539(83)80175-5

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✦ Synopsis

presence ofdifferent OH-rotamers in 18 hydroxy steroids dissolved in Ccl, has been studied by means of the i.r. absorption band. In compounds with a triple bond at the same C-atom as to which the hydroxyl group is attached, the OH appears to be present in only one rotamer position, viz. next to the triple bond. It is demonstrated that the OH-frequencies of these ethynyl steroids can be used to predict the frequencies of the methyl analogues, while the position of the methyl (aor p-) can be derived from the OHband parameters.

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