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Structural impact of hydrodynamic injection on mouse liver

✍ Scribed by Suda, T; Gao, X; Stolz, D B; Liu, D

Book ID
110039912
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
438 KB
Volume
14
Category
Article
ISSN
0969-7128

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## Abstract ## Background Rapid intravenous injection of a large volume of plasmid DNA (pDNA), i.e. a transfection procedure based on hydrodynamics, is known to be an efficient and liver‐specific method of __in vivo__ gene delivery. However, the gene expression is transient. ## Methods We invest