Methylation of DNA plays an important role in the control of gene expression in higher eukaryotes. This is largely achieved by the packaging of methylated DNA into chromatin structures that are inaccessible to transcription factors and other proteins. Methylation involves the addition of a methyl gr
β¦ LIBER β¦
Structural-functional organization of DNA domains in eukaryotes
β Scribed by GEORGIEV, G
- Book ID
- 122759933
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 148 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0309-1651
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## Abstract In the interphase nucleus of metazoan cells the DNA is organized in supercoiled loops anchored to a proteinaceous substructure known as the nuclear matrix (NM). The DNA is anchored to the NM by means of nonβcoding sequences of variable length known as matrix attachment regions or MARs o