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Structural-function relationship of the monkeypox inhibitor of complement enzyme (MOPICE) homolog of the vaccinia virus complements control protein

✍ Scribed by Grace M. London; Amod P. Kulkarni; Girish J. Kotwal


Book ID
116756078
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
71 KB
Volume
44
Category
Article
ISSN
0161-5890

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The vaccinia virus complement control protein (VCP) is involved in modulating the host inflammatory response by blocking both pathways of complement activity through its ability to bind C3b and C4b. Other activities arise from VCP's ability to strongly bind heparin. To map regions within VCP involve