Structural features and hypoglycemic activities of two polysaccharides from a hot-water extract of agrocybe cylindracea

✍ Scribed by Tadashi Kiho; Satoshi Sobue; Shigoe Ukai

• Book ID: 102998489
• Publisher: Elsevier Science
• Year: 1994
• Tongue: English
• Weight: 420 KB
• Volume: 251
• Category: Article
• ISSN: 0008-6215
• DOI: 10.1016/0008-6215(94)84277-9

✦ Synopsis

A glucan (AG-HNl, [a]o +24") and a heteroglycan (AG-HN2, [a], +26"1 were isolated from a hot-water extract of the fruiting bodies of Agrocybe cylindracea. The structures were investigated by a combination of chemical and spectroscopic methods. The results indicated that high molecular weight glucan AG-HNl is primarily a B-(1 + 6)-branched (14 3)-P-p-glucan containing small amounts of (1 + 4)-linked and (1 + 6)-linked glucopyranosyl residues. Low molecular weight heteroglycan AG-HN2 gives galactose, glucose, fucose, and mannose on hydrolysis and appears to be chiefly composed of (14 6)-linked gluco-and galacto-pyranosyl residues, many of them branched, and various nonreducing terminal residues. AG-HNl showed a remarkable hypoglycemic activity in both normal and streptozotocin-induced diabetic mice by ip administration, and its activity was higher than that of AG-HN2.