Structural evidence for substrate-induced synergism and half-sites reactivity in biotin carboxylase

On the mechanism of the Hg2+ and base in

On the mechanism of the Hg2+ and base induced hydrolysis reactions of the β2-(RR, SS)-Co (trien) (glyOR)Cl2+ions (R = H, C2H5), evidence for the site of deprotonation in the reactive conjugate base

✍ David A. Buckingham; Werner Marty; Alan M. Sargeson 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 German ⚖ 894 KB

## Acid hydrolysis of the ester function in A-( -)589-fi2-(RR)-[Co (trien) (glyOEt)C1I2+ (( -)-1) produces optically pure A-( -)589$2-(RR)-[CO (trien) (glyOH)C1I2+ (( -)-4). Hg2+ induced removal of chloride in (-)-4 follows the rate law kobs=kHg [Hg2+] with kHg=(1.36+0.03)x 1 0 -2 ~-l s -' , 25",