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Structural elucidation of underivatized gangliosides by electrospray-ionization tandem mass spectrometry (ESIMS/MS)

✍ Scribed by Tadashi Ii; Yoko Ohashi; Yoshitaka Nagai

Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
583 KB
Volume
273
Category
Article
ISSN
0008-6215

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✦ Synopsis

The structural characterization of intact polysialogangliosides by electrospray-ionization mass spectrometry (ESIMS) and tandem mass spectrometry (MS/MS) is described. The negative-ion ESI mass spectra of gangliosides 1 such as a tetrasialoganglioside GQlb, showed molecularly related ions 2 with high sensitivity and accuracy. Collision-induced dissociation (CID) MS/MS provided adequate information to characterize the number and positions of sialic acids. ESIMS and CIDMS/MS techniques were applied successfully also in the positive-ion mode for characterization of intact gangliosides. Two isomeric disialogangliosides, GDla and GDlb, are distinguishable from one another by CIDMS/MS in both negative-and positive-ion modes. The technique is readily applicable to structural analyses such as determining the positional isomers of glycoconjugates.

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