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Structural elucidation of impurities in 5-n-butyl-4-{4-[2-(1H-tetrazole-5-yl)-1H-pyrrol-1-yl]phenylmethyl}-2,4-dihydro-2-(2,6-dichlorophenyl)-3H-1,2,4-triazol-3-one (Ib), a novel nonpeptide angiotensin AT1 receptor antagonist

✍ Scribed by Ting Gao; Yaxuan Liu; Yibing Ji; Xiaoming Wu; Jinyi Xu


Book ID
113743379
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
520 KB
Volume
66
Category
Article
ISSN
0731-7085

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## Abstract magnified image One‐pot reaction of 3‐aryl‐5‐methyl‐1,3,4‐oxadiazolin‐2‐ones **1a‐g** with ethanolamine yielded the 4‐(2‐hydroxyethyl)‐2‐aryl‐5‐methyl‐2,4‐dihydro‐3__H__‐1,2,4‐triazolin‐3‐ones **2a‐g** which were converted to the azido compounds **6a‐g**. These azides on 1,3‐dipolar cy