✦ LIBER ✦

Structural Effects of Covalent Inhibition of Phospholipase A2 Suggest Allosteric Coupling between Membrane Binding and Catalytic Sites

✍ Scribed by Tatulian, Suren A.

Book ID: 118515725
Publisher: Biophysical Society
Year: 2003
Tongue: English
Weight: 241 KB
Volume: 84
Category: Article
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(03)74985-6

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Structural and Functional Effects of Try

Structural and Functional Effects of Tryptophans Inserted into the Membrane-binding and Substrate-binding Sites of Human Group IIA Phospholipase A 2†

✍ Nemec, Kathleen N.; Pande, Abhay H.; Qin, Shan; Bieber Urbauer, Ramona J.; Tan, 📂 Article 📅 2006 🏛 American Chemical Society 🌐 English ⚖ 553 KB

Aspirin induces its anti-inflammatory ef

Aspirin induces its anti-inflammatory effects through its specific binding to phospholipase A 2 : Crystal structure of the complex formed between phospholipase A 2 and aspirin at 1.9 Å resolution

✍ Singh, Rajendra Kumar; Ethayathulla, A.S.; Jabeen, Talat; Sharma, Sujata; Kaur, 📂 Article 📅 2005 🏛 Informa plc 🌐 English ⚖ 446 KB

Simultaneous inhibition of anti-coagulat

Simultaneous inhibition of anti-coagulation and inflammation: crystal structure of phospholipase A2 complexed with indomethacin at 1.4 Å resolution reveals the presence of the new common ligand-binding site

✍ Nagendra Singh; Ramasamy Prem Kumar; Sanjit Kumar; Sujata Sharma; Rafia Mir; Pun 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 533 KB

## Abstract A novel ligand‐binding site with functional implications has been identified in phospholipase A~2~ (PLA~2~). The binding of non‐steroidal anti‐inflammatory agent indomethacin at this site blocks both catalytic and anti‐coagulant actions of PLA~2~. A group IIA PLA~2~ has been isolated fr