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Structural Differences in Triosephosphate Isomerase from Different Species and Discovery of a Multitrypanosomatid Inhibitor †

✍ Scribed by Olivares-Illana, Vanesa; Pérez-Montfort, Ruy; López-Calahorra, Francisco; Costas, Miguel; Rodríguez-Romero, Adela; Tuena de Gómez-Puyou, Marieta; Gómez Puyou, Armando

Book ID
120933638
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
107 KB
Volume
45
Category
Article
ISSN
0006-2960

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## Abstract Triosephosphate isomerase (TIM) is a dimeric enzyme consisting of 2 identical subunits. Trypanosomal TIM can be crystallized in 4 different spacegroups: P2^1^2^1^2^1^, C2(big cell), C2(small cell), and P1. The P1 crystal form only grows in the presence of 1.4 M DMSO; there are 2 DMSO bi