Structural Determinants of Metal Selectivity in Prokaryotic Metal-responsive Transcriptional Regulators
β Scribed by Mario A. Pennella; David P. Giedroc
- Publisher
- Springer Netherlands
- Year
- 2005
- Tongue
- English
- Weight
- 887 KB
- Volume
- 18
- Category
- Article
- ISSN
- 1572-8773
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Metal-responsive transcription factor-1 (MTF-1), which is involved in sensing heavy metal load, induces the transcription of several protective genes. The mouse Mtf-1 gene is essential, and Mtf-1 Γ/Γ embryos die from liver degeneration. We showed that DNA synthesis induced in hepatocytes by epiderma
## Abstract DNAzymes are catalytically active DNA molecules that use metal cofactors for their enzymatic functions. While a growing number of DNAzymes with diverse functions and metal selectivities have been reported, the relationships between metal ion selectivity, conserved sequences and structur