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Structural determinants of ion selectivity in brain calcium channel

✍ Scribed by Man-Suk Kim; Takashi Morii; Li-Xin Sun; Keiji Imoto; Yasuo Mori

Book ID: 115927212
Publisher: Elsevier Science
Year: 1993
Tongue: English
Weight: 477 KB
Volume: 318
Category: Article
ISSN: 0014-5793
DOI: 10.1016/0014-5793(93)80009-j

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## Structure-function studies have shown that it is possible to convert a sodium channel to a calcium-selective channel by a single amino acid substitution in the selectivity filter locus. Ion permeation through the "model selectivity filter" was modeled with a reduced set of functional groups repr