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Structural correlation between apomorphine and LSD: Involvement of dopamine as well as serotonin in the actions of hallucinogens

✍ Scribed by David E. Nichols

Publisher: Elsevier Science
Year: 1976
Tongue: English
Weight: 599 KB
Volume: 59
Category: Article
ISSN: 0022-5193
DOI: 10.1016/s0022-5193(76)80030-6

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✦ Synopsis

It is suggested that the action of LSD and other hallucinogens depends, not only on stimulation of serotonin receptors, but also on stimulation of central dopamine receptors. Both pharmacological and structuralchemical evidence is presented to support the latter hypothesis. A structural correlation is also demonstrated between LSD and apomorphine, and the probable dopaminergic element in LSD is discussed.

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